Drug Name

Celebrex (Celecoxib)

Drug Uses

Celecoxib is tolerant of for the relief of pain, fever, nodule, and tenderness caused by osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. Celecoxib does not ward the progression of either category of arthritis. It reduces only the symptoms and signs of arthritis. Celecoxib has been approved for patients with familial FAP who arrange not had their colons removed. Celebrex also is approved for the basso-rilievo 'low relief' of acute pain and the spasm of menstrual cramps (beginning dysmenorrhea).

How to use

The lowest useful dose should be tempered to for each patient. For the conduct of osteoarthritis, the dose most of the time is 100 mg twice habitually or 200 mg as a single portion. For rheumatoid arthritis, the quantity usually is 100 or 200 mg twice commonplace. For acute pain or menstrual cramps, the administer is 400 mg as a single administer on the first day, followed by an additional 200 mg if needed, then 200mg twice every day as needed. For FAP, the recommended administer is 400 mg twice routine.

Drug Class and Mechanism

Celecoxib is a nonsteroidal anti-fiery drug (NSAID) that is habituated to to treat arthritis, hurt, menstrual cramps, and colonic polyps. Prostaglandins are chemicals that are noted contributors to the inflammation of arthritis that causes the smarting, fever, swelling and tenderness. Celecoxib blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in discredit concentrations of prostaglandins. As a consequence, redness and its accompanying pain, fever, bulge and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less swelling and ulceration of the stomach and intestine (at least with small-term treatment) and does not block with the clotting of blood. NSAIDs possess been found to control the formation and reduce the expanse of polyps in patients with the genetic plague, familial adenomatous polyposis (FAP). In FAP, patients show large numbers of polyps in their colons, and the polyps invariably ripen into malignant. The only prescription of FA

Missed Dose

Agree to the missed dose as straightway as you remember. If it is almost beforehand for the next dose, jump the dose you missed and remove only the next regularly scheduled portion as directed. Do not take a duplicate dose of this medication unless your doctor directs differently.

Storage

Capsules should be stored at 25 degrees C (77 degrees F). It is okay for ephemeral periods in temperatures between 15-30 degrees C (59-86 degrees F).

Warnings/Precautions

There are no restrictions on scoff, beverages, or activity while entrancing celecoxib unless otherwise directed by your doctor. Concomitant use of celecoxib with aspirin or other NSAIDs (e.g., ibuprofen, naproxen, etc.) may increasing the occurrence of stomach and intestinal ulcers. Fluconazole (Diflucan) increases the concentration of celecoxib in the carcass by inhibiting the breakdown of celecoxib in the liver. For that reason, treatment with celecoxib should be initiated at the lowest recommended doses in patients who are attractive fluconazole. Celecoxib increases the concentration of lithium (Eskalith) in the blood by 17%. The case, lithium therapy should be closely monitored during and after remedy with celecoxib. Persons, prepossessing the anticoagulant (blood thinner) warfarin (Coumadin), should require their blood tested when initiating or changing celecoxib treatment, specifically in the first few days, for any changes in the effects of the anticoagulant. Persons, who liquid refreshment more than 3 dipsomaniac bevera

Possible Side Effects

Although craving and intestinal ulcers suggest itself to with the use of celecoxib, their degree is less than with other NSAIDs in snappish-term studies. Celecoxib does not intercede with the function of the blood platelets and, as a development, does not reduce clotting and take the lead to increased bleeding like other NSAIDs. The most overused adverse effects are bother, abdominal pain, dyspepsia, diarrhea, nausea, flatulence and insomnia. Other side effects classify fainting, kidney default, heart failure, aggravation of hypertension, thorax ' pain, ringing in the ears, deafness, relish and intestinal ulcers, bleeding, blurred plan, anxiety, photosensitivity, avoirdupois gain, water retention, flu-like symptoms, drowsiness and weak point. Allergic reactions can develop with celecoxib. Individuals who be subjected to developed allergic reactions (headlong, itching, difficulty breathing) from sulfonamides (e.g., Bactrim), aspirin or other NSAIDs may feel an allergic reaction to celecoxib and should not conduct celecoxib

More Information

Proclaim your doctor directly if you develop abdominal toil, tenderness, or discomfort; nausea; bloody spew out; bloody, black, or bide one's time stools; unexplained authority gain; swelling or grade retention; fatigue or stupor; a skin rash; itching; yellowing of the husk or eyes;\\"flu-like\\" symptoms; or out of the ordinary bruising or bleeding. These symptoms could be primeval signs of dangerous side effects. If you sustain any of the following serious side effects, blockage taking celecoxib and beg medical treatment or call your doctor at the drop of a hat: an allergic reaction (predicament breathing; closing of your throat; protrusion of your lips, gaffe, or face; or hives). Other, less of consequence side effects may be more fitting to occur. Continue to caricature celecoxib and talk to your doctor if you observation flatulence or diarrhea; dizziness; difficulty; or insomnia. Side effects, other than those listed here, may also enter someone's head. Talk to your doctor nearby any side effect that seems strange or that is especially bothersome.